Restore function

PHYS-STROKE - Physical Fitness Training in Subacute Stroke

Controlled, randomized study of aerobic fitness training in the subacute phase after stroke.
More information/project description

Research Group Flöel

Project Desription

Given the rising number of strokes worldwide, and the large number of individuals left with disabilities after stroke, novel strategies to reduce disability, increase functions in the motor and the cognitive domains, and improve quality of life are of major importance. Physical activity is a promising intervention to address these challenges but, as yet, there is no study demonstrating definite outcomes. Our objective is to assess whether additional treatment in the form of physical fitness-based training for patients early after stroke will provide benefits in terms of functional outcomes, in particular gait speed and the Barthel Index (co-primary outcome measures) reflecting activities of daily living (ADL). We will gather secondary functional outcomes as well as mechanistic parameters in an exploratory approach. The ultimate goal of this endpoint-blinded, phase III randomised controlled trial is to provide evidence to guide post-stroke physical fitness-based rehabilitation programmes, and to elucidate the mechanisms underlying this intervention.

Responsible Principal Investigator
Prof. Agnes Flöel, M.D.
Center for Stroke Research Berlin
Charité - Universitätsmedizin Berlin

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