Prevent complications


INSPiRE-TMS stands for Intensified Secondary Prevention intending a Reduction of vascular re-events in patients with TIA or Minor Stroke). Implementation of a supported secondary prevention program in patients with minor stroke or TIA and evaluation in a randomized controlled trial.
More information/project description

Research Group Audebert

Project description

Several evidence-based strategies are available for post-acute secondary prevention after stroke including blood-pressure control, cholesterol lowering, antiplatelet treatment in arterial stroke etiology and oral anticoagulation in patients with atrial fibrillation. These measures are often not (sufficiently) practiced in routine care because patients underestimate the need of thorough secondary prevention or are not able to follow the given recommendation in long term. In contrast to other disease conditions, no disease management program has been established for patients after stroke or TIA and patient do not receive tailored outpatient care, therefore.

We have developed a support program for better protection of patients against new vascular events (recurrent stroke or myocardial infarction). This program has shown to improve the control of risk factors and medication adherence in a preparative study. Currently, we examine the effectiveness of this support program in a large multicenter randomized study regarding reduction of major vascular events. The study is conducted in Berlin at all Charité campuses or at the Vivantes-Auguste-Viktoria Hospital and outside Berlin in Aarhus/Denmark, Munich and Ludwigshafen. We have included almost 2100 patients in the study and expect the results early 2019.


Principal Investigator

  • Prof. Dr. med. Heinrich A. Audebert, MD

Steering Committee

  • Dr. Inga Laumeier
  • Dr. Michael Ahmadi
  • Dr. Thomas Ihl
  • Dr. Maureen Steinicke
  • Gabriele Nieweler

Prevention and Study Nurses

  • Sabine Wunderlich
  • Gabriela May
  • Katrin Hayens

Additional researchers

  • Dr. med. Ramanan Ganeshan
  • Philipp Klyscz
  • Dr. med. Juliane Herm
  • PD. Dr. med. Jan Scheitz

Endpoint committee

  • Prof. Dr. Peter Marx, MD
  • Prof. Dr. Otto Busse, MD
  • Prof. Dr. Friedrich Köhler, MD

Data Monitoring Committee

  • Prof. Dr. Pierre Amarenco, Paris, France
  • Prof. Dr. Jakoba Greving, Utrecht, Netherlands

Cooperations and Research Partners

  • University Hospital Aarhus, Denmark: Dr. Paul von Weitzel-Mudersbach
  • Klinikum Ludwigshafen: Prof. Dr. Armin Grau, Susanne Streib
  • Klinikum Rechts der Isar der Technischen Universität München: Prof. Dr. med. Bernhard Hemmer, Dr. med. Christian Seifert
  • Dr. med. Martin Wimmer, Praxis am Prinzregentenplatz, München
  • Prof. Dr. med. Wolfram Döhner, Center for Stroke Research Berlin
  • Prof. Dr. med. Jochen Fiebach, Center for Stroke Research Berlin
  • Prof. Dr. med. Michael Michelson, Klinik für Augenheilkunde, Universität Erlangen
  • Prof. Dr. med. Holger Gerhard, Max-Delbrück-Centrum, Berlin-Buch


  • Bundesministerium für Bildung und Forschung (BMBF)
  • Stiftung Deutsche Schlaganfall-Hilfe
  • Pfizer Deutschland
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