Prevent complications

AMINO-Stroke - Effect of Essential Amino Acids on Muscle Size and Strength in Patients with Acute Ischemic Stroke during Rehabilitation

This study assess the effect of essential amino acid supplementation on muscle wasting, muscle strength, mobility, and self-dependence in patients during rehabilitation after acute stroke.
More information/project description

Research Group Döhner

Project Description

Metabolic regulation of muscle tissue may significantly change after acute ischemic stroke. A range of mechanisms are involved in what can best be described globally as catabolic over-activation and anabolic blunting. Multiple regulatory pathways have been addressed in studies in our group including neuroendocrine activation, inflammation, fever, increased free oxygen radical accumulation, systemic hormonal imbalances, impaired appetite, changed energy expenditure and others.  The resulting muscle loss will aggravate functional impairment and patient disability beyond the neurological deficit. To investigate these changes, our group has performed observational longitudinal studies in stroke patients (BoSSS; German Clinical Trials Registry No DRKS00000514) as well as studies with experimental models of stroke related wasting.

Based on those results, novel interventional concepts are now being tested in randomized controlled interventional trials now (AMINO-Stroke, DRKS-ID: DRKS00005577). The aim is to prevent or attenuate muscle tissue loss, atrophy and sarcopenia. Improved skeletal muscle metabolic and functional capacity will increase response to rehabilitation efforts and improve long-term patient outcome.

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