Bob Siegerink, Ph.D.

Research Group Siegerink

Bob Siegerink, Ph.D.
Charité, Center for Stroke Research Berlin
Clinical Epidemiology and Health Services Research in Stroke (CEHRiS)
bob.siegerink(at)charite.de

Profile

Research group Siegerink works on several projects aimed to unravel the causes as well as the short- and long-term consequences of stroke. The group provides methodological support to researchers from other research groups of the CSB, which has resulted in some projects with a more methodological focus. Besides his work in vascular neurology, Bob Siegerink has a strong interest in causal inference and scientific integrity, which resulted in several scientific projects, courses and collaborations.

Selected Publications

Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke.
Holman C, Piper SK, Grittner U, Diamantaras AA, Kimmelman J, Siegerink B, Dirnagl U.
PLoS Biol. 2016 Jan 4;14(1):e1002331. doi: 10.1371/journal.pbio.1002331.
PMID:26726833

Recurrence and Mortality in Young Women With Myocardial Infarction or Ischemic Stroke: Long-term Follow-up of the Risk of Arterial Thrombosis in Relation to Oral Contraceptives (RATIO) Study.
Maino A, Siegerink B, Algra A, Peyvandi F, Rosendaal FR.
JAMA Intern Med. 2016 Jan;176(1):134-6. doi: 10.1001/jamainternmed.2015.6523.
PMID:26595612

Hypercoagulability and the risk of myocardial infarction and ischemic stroke in young women.
Siegerink B, Maino A, Algra A, Rosendaal FR.
J Thromb Haemost. 2015 Sep;13(9):1568-75. doi: 10.1111/jth.13045.
PMID:26178535

Impetus

Stroke is a complex disease that can have a large impact on an individual. To understand how we can minimize this impact, or perhaps even prevent its occurrence, a thorough understanding of the causes of stroke is pivotal. By understanding what mechanisms lead to a stroke, we open up new doors for treatment and prevention. I worked on several projects that show that ischemic stroke is, at least in part, caused by an increased clotting potential of an individual. Perhaps such a hypercoagulable state is a good target for the prevention of ischemic stroke and related diseases? But more knowledge on the causes of stroke will lead to an immediate change in the daily practice on how to take care of stroke patients. To do so, we also need to understand what the consequences of the stroke are. For example, which stroke patients have the highest risk of a second stroke, and how can we identify the patients that are likely to receive suboptimal care? 

Methodological research

Our team helps other research groups at the CSB to properly design and analyze their studies. Through their questions we sometimes stumble upon new methods and statistics that might be useful in stroke research. New research projects, where we combine knowledge from clinical and pre-clinical sciences are the result. This includes projects on

  • The use of non-parametric statistical methods for ordinal data analyses in stroke trials
  • The use of telephone interviews to establish functional outcome after stroke
  • The impact of misclassification on different types of confounding adjustment/elimination strategies

Most Important Projects

Protect brain

HIND – Hypercoagulability in Neurovascular Disorders

This research project transforms laboratory knowledge into epidemiological research questions in order to investigate the clinical relevance of the role of hypercoagulability in neurovascular diseases.
More information/project description

Prevent complications

MAS – Managing Aftercare for Stroke

This observational study is designed to evaluate remaining deficits of patients who suffered a stroke months and years ago.
More information/project description

Restore function

NAVICARE – patient-oriented health care research

NAVICARE creates a regional, active network for patient-oriented health care research under the project management of the Institute for Public Health.
More information/project description

Protect brain

PROSCIS-B – The CSB Prospective Stroke Cohort

This experiment investigates the process of stroke and the risk of sequelae.
More information/project description

Further Projects

Methodology Research
Our team helps other research groups at the CSB to properly design and analyze their studies. Through their questions we sometimes stumble upon new methods and statistics that might be useful in stroke research. New research projects, where we combine knowledge from clinical and pre-clinical sciences are the results.

B-SPATIAL
Stroke is a leading cause of death and disability. However, improving diagnostics and treatments such as thrombolysis and endovascular therapy have substantially reduced the burden of this disease. The B-SPATIAL register (Berlin – Specific acute therapy in ischemic or haemorrhagic stroke with long term follow–up) captures the processes during acute care of stroke patients and is a unique opportunity to assess their effects on functional outcome. Patients will be contacted via telephone three months after the event.   

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