Jan F. Scheitz

Research Group Scheitz

PD Jan F. Scheitz, M.D.
Charité, Center for Stroke Research Berlin
Heart brain interaction in stroke – "Research Group Integrative cardio-neurology"
jan.scheitz(at)charite.de

Profile

Jan Scheitz is a clinician-scientist at the Charité Department of Neurology at the Benjamin Franklin Campus (CBF). His main scientific interest is exploring the interaction between brain and heart. He is especially involved in projects dedicated to the pathomechanisms and prognostic significance of cardiac complications in patients who suffered an ischaemic stroke.

List of Publications / Charité Research Data Base
Researchgate

Selected Publications

Stroke-heart syndrome: clinical presentation and underlying mechanisms.
Scheitz JF, Nolte CH, Doehner W, Hachinski V, Endres M.
Lancet Neurol. 2018 Dec;17(12):1109-1120. doi: 10.1016/S1474-4422(18)30336-3. Epub 2018 Oct 26. Review.
PMID: 30509695

Coronary Angiographic Findings in Acute Ischemic Stroke Patients With Elevated Cardiac Troponin: The Troponin Elevation in Acute Ischemic Stroke (TRELAS) Study.
Mochmann HC*, Scheitz JF*, Petzold GC, Haeusler KG, Audebert HJ, Laufs U, Schneider C, Landmesser U, Werner N, Endres M*, Witzenbichler B*, Nolte CH*; TRELAS Study Group.
Circulation. 2016 Mar 29;133(13):1264-71. doi: 10.1161/CIRCULATIONAHA.115.018547. Epub 2016 Mar 1.
PMID: 26933082
* contributed equally

High-sensitivity cardiac troponin T and severity of cerebral white matter lesions in patients with acute ischemic stroke.
von Rennenberg R, Siegerink B, Ganeshan R, Villringer K, Doehner W, Audebert HJ, Endres M, Nolte CH*, Scheitz JF*.
J Neurol. 2019 Jan;266(1):37-45. doi: 10.1007/s00415-018-9085-3. Epub 2018 Oct 11.
PMID: 30311052
* contributed equally

Insular cortex lesions, cardiac troponin, and detection of previously unknown atrial fibrillation in acute ischemic stroke: insights from the troponin elevation in acute ischemic stroke study.
Scheitz JF, Erdur H, Haeusler KG, Audebert HJ, Roser M, Laufs U, Endres M, Nolte CH.
Stroke. 2015 May;46(5):1196-201. doi: 10.1161/STROKEAHA.115.008681. Epub 2015 Apr 2.
PMID: 25835563 

Clinical Selection Strategies to Identify Ischemic Stroke Patients With Large Anterior Vessel Occlusion: Results From SITS-ISTR (Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Registry).
Scheitz JF*, Abdul-Rahim AH*, MacIsaac RL, Cooray C, Sucharew H, Kleindorfer D, Khatri P, Broderick JP, Audebert HJ, Ahmed N, Wahlgren N, Endres M, Nolte CH*, Lees KR*; SITS Scientific Committee.
Stroke. 2017 Feb;48(2):290-297. doi: 10.1161/STROKEAHA.116.014431. Epub 2017 Jan 13. Erratum in: Stroke. 2017 Mar;48(3):e95.
PMID: 28087804
* contributed equally

Predictors of new remote cerebral microbleeds after IV thrombolysis for ischemic stroke.
Braemswig TB, Villringer K, Turc G, Erdur H, Fiebach JB, Audebert HJ, Endres M, Nolte CH*, Scheitz JF*.
Neurology. 2019 Jan 23. pii: 10.1212/WNL.0000000000006915. doi: 10.1212/WNL.0000000000006915. [Epub ahead of print]
PMID: 30674591
* contributed equally

Statins and risk of poststroke hemorrhagic complications.
Scheitz JF, MacIsaac RL, Abdul-Rahim AH, Siegerink B, Bath PM, Endres M, Lees KR, Nolte CH; VISTA collaboration.
Neurology. 2016 Apr 26;86(17):1590-6. doi: 10.1212/WNL.0000000000002606. Epub 2016 Mar 25.
PMID: 27016519

Statin Treatment in Patients With Intracerebral Hemorrhage.
Endres M, Nolte CH, Scheitz JF.
Stroke. 2018 Jan;49(1):240-246. doi: 10.1161/STROKEAHA.117.019322. Epub 2017 Nov 30. Review. No abstract available.
PMID: 29191849

Impetus

The prognosis of patients who suffered an ischaemic stroke is significantly influenced by cardiac complications. In the early phase after the stroke, for instance, relevant cardiac damage (acute myocardial damage, high-sensitivity troponin hs-cTn) and function and rhythm disturbances are observed in around 20 % of patients. There is increasing evidence that these changes are often based on stroke-related problems in the central autonomic control of the heart (stroke-heart syndrome). However, many of these cases are difficult to distinguish from an acute coronary syndrome in everyday clinical practice. In our projects, we want to improve clinical algorithms for the treatment of stroke patients with acute myocardial damage and identify therapeutic objectives. We also focus on individual risk prediction of stroke recurrence, cognitive disorders and atrial fibrillation using cardiac biomarkers.

Most Important Project

Prevent complications

CORONA-IS

The primary objective of the CORONA-IS study (CardiOmyocyte injuRy follOwing Acute Ischemic Stroke) is to explore the developmental mechanisms of stroke-associated, acute myocardial damage in an interdisciplinary approach.
More information/project description

Similar projects

Team

Team research group Scheitz, from left: Helena Stengl; Leonie Broersen, M.Sc; PD Jan F. Scheitz, M.D.; Ramanan Ganeshan, M.D.; Jess Lim
Team research group Scheitz
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