Jan F. Scheitz

Research Group Scheitz

PD Jan F. Scheitz, M.D.
Charité, Center for Stroke Research Berlin
Heart brain interaction in stroke – "Research Group Integrative cardio-neurology"


Jan Scheitz is a clinician-scientist and senior physician at the Charité Department of Neurology at the Benjamin Franklin Campus (CBF). His main scientific interest is exploring the interaction between brain and heart. He is especially involved in projects dedicated to the pathomechanisms and prognostic significance of cardiac complications in patients who suffered an ischaemic stroke.

List of Publications / Charité Research Data Base

Selected Publications

Stroke-heart syndrome: clinical presentation and underlying mechanisms.
Scheitz JF, Nolte CH, Doehner W, Hachinski V, Endres M.
Lancet Neurol. 2018 Dec;17(12):1109-1120. doi: 10.1016/S1474-4422(18)30336-3. Epub 2018 Oct 26. Review.
PMID: 30509695

Coronary Angiographic Findings in Acute Ischemic Stroke Patients With Elevated Cardiac Troponin: The Troponin Elevation in Acute Ischemic Stroke (TRELAS) Study.
Mochmann HC*, Scheitz JF*, Petzold GC, Haeusler KG, Audebert HJ, Laufs U, Schneider C, Landmesser U, Werner N, Endres M*, Witzenbichler B*, Nolte CH*; TRELAS Study Group.
Circulation. 2016 Mar 29;133(13):1264-71. doi: 10.1161/CIRCULATIONAHA.115.018547. Epub 2016 Mar 1.
PMID: 26933082
* contributed equally

High-sensitivity cardiac troponin T and severity of cerebral white matter lesions in patients with acute ischemic stroke.
von Rennenberg R, Siegerink B, Ganeshan R, Villringer K, Doehner W, Audebert HJ, Endres M, Nolte CH*, Scheitz JF*.
J Neurol. 2019 Jan;266(1):37-45. doi: 10.1007/s00415-018-9085-3. Epub 2018 Oct 11.
PMID: 30311052
* contributed equally

Insular cortex lesions, cardiac troponin, and detection of previously unknown atrial fibrillation in acute ischemic stroke: insights from the troponin elevation in acute ischemic stroke study.
Scheitz JF, Erdur H, Haeusler KG, Audebert HJ, Roser M, Laufs U, Endres M, Nolte CH.
Stroke. 2015 May;46(5):1196-201. doi: 10.1161/STROKEAHA.115.008681. Epub 2015 Apr 2.
PMID: 25835563 

Clinical Selection Strategies to Identify Ischemic Stroke Patients With Large Anterior Vessel Occlusion: Results From SITS-ISTR (Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Registry).
Scheitz JF*, Abdul-Rahim AH*, MacIsaac RL, Cooray C, Sucharew H, Kleindorfer D, Khatri P, Broderick JP, Audebert HJ, Ahmed N, Wahlgren N, Endres M, Nolte CH*, Lees KR*; SITS Scientific Committee.
Stroke. 2017 Feb;48(2):290-297. doi: 10.1161/STROKEAHA.116.014431. Epub 2017 Jan 13. Erratum in: Stroke. 2017 Mar;48(3):e95.
PMID: 28087804
* contributed equally

Predictors of new remote cerebral microbleeds after IV thrombolysis for ischemic stroke.
Braemswig TB, Villringer K, Turc G, Erdur H, Fiebach JB, Audebert HJ, Endres M, Nolte CH*, Scheitz JF*.
Neurology. 2019 Jan 23. pii: 10.1212/WNL.0000000000006915. doi: 10.1212/WNL.0000000000006915. [Epub ahead of print]
PMID: 30674591
* contributed equally

Association Between High-Sensitivity Cardiac Troponin and Risk of Stroke in 96 702 Individuals: A Meta-Analysis.
Broersen LHA, Stengl H, Nolte CH, Westermann D, Endres M, Siegerink B, Scheitz JF.
Stroke. 2020 Feb 10:STROKEAHA119028323. doi: 10.1161/STROKEAHA.119.028323. [Epub ahead of print]
PMID: 32078461

Statin Treatment in Patients With Intracerebral Hemorrhage.
Endres M, Nolte CH, Scheitz JF.
Stroke. 2018 Jan;49(1):240-246. doi: 10.1161/STROKEAHA.117.019322. Epub 2017 Nov 30. Review. No abstract available.
PMID: 29191849


Acute myocardial injury (high-sensitivity troponin hs-cTn) and heart failure and cardiac arrhythmia are observed in approximately 20 % of patients. There is growing evidence that these changes can be due to stroke-related disturbance of normal autonomic control of the heart ("stroke-heart syndrome"). However, many of these cases are difficult to distinguish from an acute coronary syndrome in everyday clinical practice. In our projects, we aim to improve clinical algorithms for the treatment of stroke patients with acute myocardial injury and identify therapeutic targets. We also focus on individual risk prediction of stroke recurrence, cognitive disorders and atrial fibrillation using cardiac biomarkers, and are interested in takotsubo syndrome after neurological disorders.

Most Important Project

Prevent complications


The primary objective of the CORONA-IS study (CardiOmyocyte injuRy follOwing Acute Ischemic Stroke) is to explore the developmental mechanisms of stroke-associated, acute myocardial damage in an interdisciplinary approach.
More information/project description

Similar projects


  • Helena Stengl, M.D.
  • Ramanan Ganeshan, M.D.
  • Simon Hellwig, M.D.
  • Markus Klammer
  • Jess Lim

  • former team member: Leonie Broersen, Ph.D.
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