Prof. Christian Nolte, M.D.

Research Group Nolte

Prof. Christian H. Nolte, M.D.
Charité, Center for Stroke Research
Berlin Department of Neurology and University Outpatient Clinic Campus Benjamin Franklin
christian.nolte(at)charite.de

Profile

Christian Nolte is a consultant in the Department of Neurology and heads the comprehensive Stroke Unit at the Charite Campus Benjamin Franklin (CBF). He runs the stroke thrombolysis and endovascular recanalization register of the CBF. Dr. Nolte’s major scientific interest is the heart-and-brain interaction and treatment of acute ischemic stroke.

List of Publications / Charité Research Data Base

Selected Publications

Effects of Prehospital Thrombolysis in Stroke Patients With Prestroke Dependency.
Nolte CH, Ebinger M, Scheitz JF, Kunz A, Erdur H, Geisler F, Braemswig TB, Rozanski M, Weber JE, Wendt M, Zieschang K, Fiebach JB, Villringer K, Grittner U, Kaczmarek S, Endres M, Audebert HJ.
Stroke. 2018 Mar;49(3):646-651.
PMID:29459395

Effects of Ultraearly Intravenous Thrombolysis on Outcomes in Ischemic Stroke: The STEMO (Stroke Emergency Mobile) Group.
Kunz A, Nolte CH, Erdur H, Fiebach JB, Geisler F, Rozanski M, Scheitz JF, Villringer K, Waldschmidt C, Weber JE, Wendt M, Winter B, Zieschang K, Grittner U, Kaczmarek S, Endres M, Ebinger M, Audebert HJ.
Circulation. 2017 May 2;135(18):1765-1767
PMID:28461420

Stroke in right dorsal anterior insular cortex Is related to myocardial injury.
Krause T, Werner K, Fiebach JB, Villringer K, Piper SK, Haeusler KG, Endres M, Scheitz JF, Nolte CH.
Ann Neurol. 2017 Apr;81(4):502-511.
PMID:28253544

Impact of heart rate on admission on mortality and morbidity in acute ischaemic stroke patients - results from VISTA.
Nolte CH, Erdur H, Grittner U, Schneider A, Piper SK, Scheitz JF, Wellwood I, Bath PM, Diener HC, Lees KR, Endres M; VISTA collaborators.Eur J Neurol. 2016 Dec;23(12):1750-1756. doi: 10.1111/ene.13115.
PMID:27516056

Functional outcomes of pre-hospital thrombolysis in a mobile stroke treatment unit compared with conventional care: an observational registry study.
Kunz A, Ebinger M, Geisler F, Rozanski M, Waldschmidt C, Weber JE, Wendt M, Winter B, Zieschang K, Fiebach JB, Villringer K, Erdur H, Scheitz JF, Tütüncü S, Bollweg K, Grittner U, Kaczmarek S, Endres M, Nolte CH, Audebert HJ.
Lancet Neurol. 2016 Sep;15(10):1035-43. doi: 10.1016/S1474-4422(16)30129-6.
PMID:27430529

Statins and risk of poststroke hemorrhagic complications.
Scheitz JF, MacIsaac RL, Abdul-Rahim AH, Siegerink B, Bath PM, Endres M, Lees KR, Nolte CH; VISTA collaboration.
Neurology. 2016 Apr 26;86(17):1590-6. doi: 10.1212/WNL.0000000000002606.
PMID:27016519

Coronary Angiographic Findings in Acute Ischemic Stroke Patients With Elevated Cardiac Troponin: The Troponin Elevation in Acute Ischemic Stroke (TRELAS) Study.
Mochmann HC, Scheitz JF, Petzold GC, Haeusler KG, Audebert HJ, Laufs U, Schneider C, Landmesser U, Werner N, Endres M, Witzenbichler B, Nolte CH; TRELAS Study Group.
Circulation. 2016 Mar 29;133(13):1264-71. doi: 10.1161/CIRCULATIONAHA.115.018547.
PMID:26933082

Impetus

Many recommendations for stroke treatment are based on the results of controlled randomized trials (RCTs). Patients included in these RCTs do not necessarily represent the characteristics of common stroke populations in real life, but have rather met specific inclusion criteria. We investigate the reality of patient care outside of RCTs. We investigate which factors influence the treatment process in reality (within day-to-day practice). In addition, we identify factors that promise a decisively good prognosis, on the one hand, or warrant having second thoughts about the correct choice of treatment, on the other. Many of these factors have come to our attention because of new diagnostic tools (e.g. MRI) and were unknown at the time the RCTs were carried out (e.g. cerebral microbleeds, cerebral cavernous malformations or hyperintense vessel sign).

Of particular interest are A) heart and brain interaction (e.g. TRELAS and HEBRAS Study) and B) specific benefit-risk constellations of thrombolysis and endovascular recanalization in acute ischemic stroke (e.g. statin use, novel oral anticoagulants, renal impairment, smoking and periprocedural aspects). We collaborate with partners from Switzerland, England, France, and Finland, amongst others.

Most Important Projects

Prevent complications

HEBRAS - Heart and Brain interaction in Acute Stroke

This prospective observational study is examining whether an enhanced MRI investigation leads to a significant increase of the findings regarding the cause of stroke.
More information/project description

Prevent complications

PRAISE

The primary goal of the PRAISE study is to develop a diagnostic algorithm that allows the prediction of acute coronary syndrome in stroke patients.
More information/project description

Prevent complications

TRELAS - TRoponin ELevation in Acute Stroke

In 5-34% of patients with acute ischemic stroke increased troponins are found. Regarding the optimal care for these patients, there is little evidence.
More information/project description

Further Projects

In-hospital stroke recurrence and mortality: frequency and risk factors.

Cerebral microbleeds and risk of intracerebral hemorrhage after intravenous thrombolysis.

Team

  • Dr. med. Jan F Scheitz
  • Dr. med. Hebun Erdur
  • Dr. med. Tim-Bastian Brämswig
  • Dr. med. Merve Fritsch
  • Regina von Rennenberg

Cooperations/Research Partners

Education and Teaching

Lecturer for the qualification course "Stroke Unit course for Nurses" of the German Stroke Society (DSG)
Guest lecturer at the Berlin School of Mind and Brain

Funding

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