Research Group Meisel

Professor Andreas Meisel, M.D.
Charité, Department of Neurology, Center for Stroke Research Berlin, NeuroCure Clinical Research Center
CSB Chief Executive Director
andreas.meisel(at)charite.de

Profile

Andreas Meisel is a professor for neurology at the NeuroCure Clinical Research Center (NCRC) and the CSB, and an attending physician and neurointensivist in the Department of Neurology. He heads the Berlin Stroke Alliance. Dr. Meisel‘s group is active in the field of experimental and clinical stroke research, dissecting mechanisms and functional relevance of stroke-induced suppression and modulation of the immunity as well as of endogenous brain protection and repair programs.

A.Meisel@NeuroCure

List of Publications / Charité Research Data Base

Selected Publications

Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.
Engel O, Akyüz L, da Costa Goncalves AC, Winek K, Dames C, Thielke M, Herold S, Böttcher C, Priller J, Volk HD, Dirnagl U, Meisel C, Meisel A.
Stroke. 2015 Nov;46(11):3232-40. doi: 10.1161/STROKEAHA.115.008989.
PMID:26451017

Prevention of stroke-associated pneumonia: where next?
Meisel A, Smith CJ.
Lancet. 2015 Nov 7;386(10006):1802-4. doi: 10.1016/S0140-6736(15)00127-0. No abstract available.
PMID:26343837

Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.
Römer C, Engel O, Winek K, Hochmeister S, Zhang T, Royl G, Klehmet J, Dirnagl U, Meisel C, Meisel A.
J Neurosci. 2015 May 20;35(20):7777-94. doi: 10.1523/JNEUROSCI.1532-14.2015.
PMID:25995466

Impetus

The acute course of stroke is often complicated by pneumonia, which constitutes a leading cause of stroke mortality and morbidity. Most clinicians assume that post-stroke pneumonia is caused by aspiration due to dysphagia. Aspiration alone, however, cannot explain the high incidence of pneumonia in acute stroke. We have previously characterized a CNS injury-induced immunodepression syndrome (CIDS) which provides a molecular explanation for the high incidence of infectious complications in stroke patients. Whereas stroke-associated pneumonia boosts autoreactive CNS antigen-specific adaptive immune responses considered to be involved in secondary damage of ischemic tissue, stroke-induced immunodepression ameliorates at least in part these responses.

Importantly, pneumonia is one of the few risk factors for poor outcome which are not only treatable but also preventable. However, measures to manage this detrimental complication have not improved over the last 20 years and pneumonia remains a serious problem in current clinical practice. Our studies will provide new diagnostic markers identifying patients at risk for post-stroke pneumonia. Moreover, we will develop new treatment approaches to prevent and attenuate post-stroke infections.

Most Important Projects

Prevent complications

Brain Gut Interaction

This project explores the following hypotheses

  • Stroke changes the gut microbiome
  • The gut microbiome affects outcome after stroke
  • Gut microbiome impacts on outcome after CNS lesion via a) effects on the immune system, including costimulation by bacterial products; b) direct humoral/metabolic signaling; and c) effects on enteral nervous system.

More information/project description

Prevent complications

Brain Immune Interaction

Given the experimental and clinical evidence that CNS injury-induced immunodepression syndrome (CIDS) fosters post-stroke infection and that infections might worsen stroke outcome, immunomodulatory therapies to reconstitute antimicrobial host immune defenses may provide a new approach to improve stroke outcome.
More information/project description

Prevent complications

MAS - Managing Aftercare for Stroke

This observational study is designed to evaluate remaining deficits of patients who suffered a stroke months and years ago.
More information/project description

Restore function

Navicare - patient-oriented health care research

NAVICARE creates a regional, active network for patient-oriented health care research under the project management of the Institute for Public Health.
More information/project description

Further Projects

In experimental models of stroke and clinical studies we are currently dissecting the complex role of the autonomic nervous system in regulating the innate and adaptive immunity following acute CNS lesions and the consequences of CIDS for the body and CNS itself. For example, we will investigate the safety of inhaled interferon-γ and its efficacy in the prevention of stroke-associated pneumonia in patients with acute severe ischemic stroke and the role of T- and B-cell-mediated CNS antigen specific autoreactive immune responses.

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