Research Group Häusler

Karl Georg Häusler, M.D.
Head of Trial Team
Charité, Centrum für Schlaganfallforschung Berlin
georg.haeusler(at)charite.de

Profile

Karl Georg Häusler is a neurologist and working as a consultant at the Department of Neurology, Charité - Universitätsmedizin Berlin, Germany. He heads the Trial Team at the Center for Stroke Research Berlin and conducts stroke trials at the Charité. As a member of the steering committee of the German Atrial Fibrillation NETwork, Karl Georg Häusler’s research focuses on heart and brain interactions in the field of stroke.

List of Publications / Charité Research Data Base

Selected Publications

Impact of standardized MONitoring for Detection of Atrial Fibrillation in Ischemic Stroke (MonDAFIS): Rationale and design of a prospective randomized multicenter study.
Haeusler KG, Kirchhof P, Heuschmann PU, Laufs U, Busse O, Kunze C, Thomalla G, Nabavi DG, Röther J, Veltkamp R, Endres M.
Am Heart J. 2016 Feb;172:19-25. doi: 10.1016/j.ahj.2015.10.010.
PMID:26856211

HEart and BRain interfaces in Acute ischemic Stroke (HEBRAS)--rationale and design of a prospective oberservational cohort study.
Haeusler KG, Grittner U, Fiebach JB, Endres M, Krause T, Nolte CH.
BMC Neurol. 2015 Oct 22;15:213. doi: 10.1186/s12883-015-0458-2.PMID:26490042

Rate of cardiac arrhythmias and silent brain lesions in experienced marathon runners: rationale, design and baseline data of the Berlin Beat of Running study.
Haeusler KG, Herm J, Kunze C, Krüll M, Brechtel L, Lock J, Hohenhaus M, Heuschmann PU, Fiebach JB, Haverkamp W, Endres M, Jungehulsing GJ.
BMC Cardiovasc Disord. 2012 Aug 31;12:69.
PMID:22938148

Impetus

Atrial fibrillation (AF) is the most frequent cardiac arrhythmia worldwide and associated with a four- to fivefold increased risk of ischemic stroke. Today, AF may account for every fifth ischemic stroke. In addition, AF patients suffering a stroke have a poorer prognosis and a higher stroke recurrence rate than do stroke patients without AF. However, paroxysmal AF often goes unnoticed (“silent”) in up to 30 % of stroke patients. Prolonged ECG monitoring and systematic analysis of ECG recording enhances detection of non-permanent AF after ischemic stroke, but data from randomized prospective trials is scarce and limited to the subset of patients with cryptogenic stroke.

Most Important Projects

Prevent complications

AF Registry - Berlin Cohort Study on Oral Anticoagulation in Patients with Atrial Fibrillation and Acute Ischemic Stroke

The study is an Investigator-initiated, prospective, multi-centre cohort study using the established collaborative group of the Berlin Stroke Register (BSR) to gather data on eligible stroke patients and to investigate in the city of Berlin about the secondary prevention for stroke and the adherence regarding the prescriptions in patients with known atrial fibrillation and ischemic stroke.
More information/project description

Prevent complications

HEBRAS - Heart and Brain interaction in Acute Stroke

This prospective observational study is examining whether an enhanced MRI investigation leads to a significant increase of the findings regarding the cause of stroke.
More information/project description

Prevent complications

MonDAFIS - Impact of standardized MONitoring for Detection of Atrial Fibrillation in Ischemic Stroke

Investigator-initiated, prospective, randomized, open-label, multi-center trial with two parallel groups. Randomization of patients happens 1:1 into one group that receives standard care and one group that receives standard care plus additional Holter ECG monitoring.
More information/project description

Further Projects

Berlin Beat of Running Study
Prospective study, NCT01428778

Team

  Interaction of HEART & BRAIN

  • Simon Hellwig (assistant physician)
  • Dr. med. Juliane Herm, (assistant physician)
  • Dr. med. Luzie Köhler, (assistant physician)
  • Johannes Schurig (assistant physician)

 MonDAFIS and Berlin AF Registry

  • Petra Dem (data manager)
  • Dr. med. Joanna Dietzel, (neurologist)
  • Eva Maria Kampschulte (study assistant, 50 %)
  • Michael Krämer (IT manager, 75%)
  • Claudia Kunze (project manager)
  • Gesa Nöhren (monitor)
  • Johannes Schurig (assistant physician, 50%)
  • Dr. med. Serdar Tütüncü, (neurologist)

 Trial Team

  • Kirsten Brade (study assistant)
  • Jadranka Denes (study assistant)
  • Rohat Geran (investigating physician)
  • Peter Harmel (investigating physician, 25 %)
  • Simon Hellwig (investigating physician, 50 %)
  • Julia Herde (quality manager, study coordinator)
  • Dr. med. Luzie Köhler, (investigating physician)
  • Stephanie Liscow (team assistant)
  • Maria Volk (study assistant)
  • Tatjana Wittenberg (senior study assistant)

Cooperations and Studies

  • Berlin AF Registry – Charité - Universitätsmedizin Berlin
  • MonDAFIS Study – Charité - Universitätsmedizin Berlin
  • AXAFA Study – Competence Network Atrial Fibrillation (AFNET) 
  • HEBRAS Study – Center for Stroke Research Berlin
  • MACPAF Study – Center for Stroke Research Berlin
  • CaMRISS Study – Center for Stroke Research Berlin
  • Berlin Beat of Running Study – Center for Stroke Research Berlin

Funding

  • German Federal Ministry of  Education and Research – HEBRAS & CaMRISS Study
  • Bayer HealthCare – MonDAFIS Study, Berlin AF Registry, Berlin Beat of Running Study
  • Sanofi Aventis – Berlin Beat of Running Study
  • Getemed AG – HEBRAS Study
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