Research Group Audebert

A support programme for secondary prevention in patients with transient ischaemic attack and minor stroke (INSPiRE-TMS): an open-label, randomised controlled trial.
Ahmadi M, Laumeier I, Ihl T, Steinicke M, Ferse C, Endres M, Grau A, Hastrup S, Poppert H, Palm F, Schoene M, Seifert CL, Kandil FI, Weber JE, von Weitzel-Mudersbach P, Wimmer MLJ, Algra A, Amarenco P, Greving JP, Busse O, Köhler F, Marx P, Audebert HJ.
Lancet Neurol. 2020 Jan;19(1):49-60. doi: 10.1016/S1474-4422(19)30369-2. Epub 2019 Nov 7.
PMID: 31708447

Functional outcomes of pre-hospital stroke thrombolysis in a Mobile Stroke Treatment Unit compared to conventional care: an observational registry study.
Kunz A, Ebinger M, Geisler F, Rozanski M, Waldschmidt C, Weber JE, Wendt M, Winter B, Zieschang K, Fiebach JB, Villringer K, Erdur H, Scheitz JF, Tütüncü S, Bollweg K, Grittner U, Kaczmarek S, Endres M, Nolte CH, Audebert HJ.
Lancet Neurol. 2016 Sep;15(10):1035-43. doi: 10.1016/S1474-4422(16)30129-6.
PMID:27430529

Cost-effectiveness estimate of prehospital thrombolysis: Results of the PHANTOM-S Study.
Gyrd-Hansen D, Olsen KR, Bollweg K, Kronborg C, Ebinger M, Audebert HJ. 
Neurology. 2015 Mar 17;84(11):1090-7. doi: 10.1212/WNL.0000000000001366.
PMID:25672925

Improved Prehospital Triage of Patients With Stroke in a Specialized Stroke Ambulance: Results of the Pre-Hospital Acute Neurological Therapy and Optimization of Medical Care in Stroke Study.
Wendt M, Ebinger M, Kunz A, Rozanski M, Waldschmidt C, Weber JE, Winter B, Koch PM, Freitag E, Reich J, Schremmer D, Audebert HJ; STEMO Consortium.
Stroke. 2015 Mar;46(3):740-5. doi: 10.1161/STROKEAHA.114.008159.
PMID:25634000

Effects of Golden Hour Thrombolysis A Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke (PHANTOM-S) Substudy.
Ebinger M, Kunz A, Wendt M, Rozanski M, Winter B, Waldschmidt C, Weber J, Villringer K, Fiebach JB, Audebert HJ.
JAMA Neurol. 2015 Jan;72(1):25-30. doi: 10.1001/jamaneurol.2014.3188.
PMID:25402214

Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute ischemic stroke: a randomized clinical trial.
Ebinger M, Winter B, Wendt M, Weber JE, Waldschmidt C, Rozanski M, Kunz A, Koch P, Kellner PA, Gierhake D, Villringer K, Fiebach JB, Grittner U, Hartmann A, Mackert BM, Endres M, Audebert HJ; STEMO Consortium.
JAMA. 2014 Apr 23-30;311(16):1622-31. doi: 10.1001/jama.2014.2850.
PMID:24756512

Stroke is a medical emergency because death of brain cells starts almost immediately after blockage of the supplying arterial vessel. Intravenous thrombolysis and catheter-based mechanical thrombectomy improve neurological outcome after ischemic stroke by recanalizing the occluded artery. However, the effectiveness of these treatments is strongly time-dependent, decreasing over time.

The potential of thrombolysis is limited by pre- and intra-hospital delays in hyperacute stroke management: a delayed emergency call, time loss in ambulance management and multiple handovers at admission and during in-hospital diagnostic workup.

We have therefore started a multilevel intervention project aiming to improve all steps of hyperacute stroke management. Our stroke awareness campaign “Berlin against Stroke” took place over a six month period in 2010. Together with the Berlin Dispatch Center, we developed a stroke identification interview algorithm for emergency calls that has enabled us to recognize more than half of acute stroke patients at dispatcher level.

Delir-Risk

Sequential improvement of patients at high risk for developing delirium during acute in-hospital stay on normal care wards with

• Development and validation of a risk score prediction manifestation of delirium
• Validation of the Nurse Delirium Score (NUDESC) on normal care wards
• Implementation of a ‘Delirium Team’ for prevention and treatment of delirium
• Controlled study investigating the effectiveness of the Delirium Team care in high-risk patients

Team

• Prof. Heinrich A. Audebert, M.D.
• Christiana Franke, M.D.
• Manuela Bergjan, Ph.D, RN
• Armin Hauß, MScN (Univ.), RN
• Monserat Peniche, BoN, RN
• Torsten Schwalbach, B.A., RN
• Max Zilezinski, (cand.) B.A., RN