Cell cycle and brain ischemia

We aim to identify new therapeutic targets for neuronal protection and regeneration in brain ischemia. Our focus is i) to study endogenous pathophysiological patterns with a focus on genes related to cell cycle control and epigenetic modulation ii) study the role of distinct candidate genes using lentiviral, neuronal-specific gene delivery for RNA interference in vitro and in vivo iii) identify the regulatory pathways involved in transcriptional control, epigenetic modulation and inflammatory actions involved in the chronic phase of brain ischemia. iv) study the impact of identified candidates on stroke outcome using transgene and knockout strategies, imaging techniques (MR imaging, near infrared imaging) and behavioural analysis after middle cerebral artery occlusion in mice.