Selected References

1.  Dreier JP, Körner K, Ebert N, Görner A, Rubin I, Back T, Lindauer U, Wolf T, Villringe A, Einhäupl KM, Lauritzen M, Dirnagl U (1998) Nitric oxide scavenging by hemoglobin or nitric oxide synthase inhibition by  N-nitro-L-arginine induce cortical spreading ischemia when K+ is increased in the subarachnoid space. J Cereb Blood Flow Metab 18:978-990

2  Dreier JP, Ebert N, Priller J, Megow D, Lindauer U, Klee R, Reuter U, Imai Y, Einhäup KM, Victorov I, Dirnagl U (2000) Products of hemolysis in the subarachnoid space induce cortical spreading ischemia and focal necrosis in rats, a model for delayed ischemic neurological deficits after subarachnoid hemorrhage? J Neurosurg 93:668 676

3.  Windmüller O, Lindauer U, Foddis M, Einhäupl KM, Dirnagl U, Heinemann U, Dreier JP (2005) Ion changes of spreading ischaemia induce rat middle cerebral arter constriction in absence of NO. Brain 128:2042-2051

4.  Dreier JP, Woitzik J, Fabricius M, Bhatia R, Major S, Drenckhahn C, Lehmann T-N, Sarrafzadeh A, Willumsen L, Hartings JA,  Sakowitz OW, Seemann JH, Thieme A, Lauritzen M, Strong AJ (2006) Delayed  ischaemic neurological deficits afte subarachnoid haemorrhage are associated with clusters of spreading depolarisations Brain 129:3224-3237

5.   Dreier JP, Major S, Manning A, Woitzik J, Drenckhahn C, Steinbrink J, Tolias C, Oliveira-Ferreira AI, Fabricius M, Hartings JA, Vajkoczy P, Lauritzen M, Dirnagl U, Bohner G, Strong AJ (2009) Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain in press

6.  Seiffert E, Dreier JP, Ivens S, Bechmann I, Tomkins O, Heinemann U, Friedman A (2004) Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex. J Neurosci 24:7829 - 7836

7.  Dreier JP, Jurkat-Rott K, Petzold GC, Tomkins O, Klingebiel R, Kopp UA, Lehmann-Horn F, Friedman A, Dichgans M (2005) Opening of the blood-brain barrier preceding a cortical edema in a severe attack of FHM type II. Neurology 64:2145-2147

8.  Tomkins O, Friedman O, Ivens S, Reiffurth C, Major S, Dreier JP, Heinemann U, Friedman A (2007) Blood-brain barrier disruption results in delayed functional and structural alterations in the rat neocortex. Neurobiol Dis 25:367-377

9.   Dreier JP, Kleeberg J, Petzold G, Priller J, Windmüller O, Orzechowski H-D, Lindauer U, Heinemann U, Einhäupl KM, Dirnagl U (2002) Endothelin-1 potently induces Leão's cortical spreading depression in vivo in the rat: A model for an endothelial trigger of migrainous aura? Brain 125:102-112

10.  Dreier JP, Kleeberg J, Alam M, Major  S, Kohl-Bareis M, Petzold GC, Victorov I, Dirnagl U, Obrenovitch TP, Priller J (2007) Endothelin-1-induced spreading depression in rats is associated with a micro area of selective neuronal necrosis. Exp Biol Med (Maywood) 232:204-213