Modules

Sometimes, less is more.

Are you interested in selected topics of the program? Instead fo completing the full Master's course, you can attend one or more modules only. A respective certificate will attest to the credit points and grade earned. Read more in the following chapter.

Specialized Qualification Needs

"The Clinical Epidemiology course was excellent. It gave me a new perspective on how to read scientific papers critically and do my own research. And though I did not attend other modules of the Master's program, I had no problem understanding the material presented in class. I strongly recommend the Clinical Epidemiology course to all professionals in the field." - Jessica Rohmann, USA

Individualized Education

Experienced professionals or sales staff may be in need of further qualification in certain areas. For those cases, we offer the option to study selected modules only. Have a look at the content and learning outcomes below.

We can even tailor module content to your very special needs and design staff training programs for your company. Contact us at master-stroke(at)charite.de.

Of course, module certificates will attest to your credits and grades. Should students decide to complete the program in full, credits will, of course, be transfered.

Time Investment

One module constitutes 5 ECTS credit points, or 150 academic hours of student invested time. Of that, 40 hours are dedicated to the teaching week incl. an online examination. The rest is used for preparing a presentation and completing a take home assignment.

Examinations

  • Online examination - 50%
  • Student presentation - 25%
  • Take home assignment - 25%

Cost

  • €1,225.00

Module 1: Basics of Cerebrovascular Medicine

Prof. Christoph Harms, M.D.
Prof. Christoph Harms, M.D.

Scientists in Charge

  • Prof. Christoph Harms, M.D.

Contributing Scientists

  • Prof. Ulrich Dirnagl, M.D.
  • Prof. Jens Dreier, M.D.
  • Christoph Drenckhahn, M.D.
  • Karen Gertz, M.D.
  • Prof. Golo Kronenberg, M.D.
  • Prof. Andreas Meisel, M.D.
  • Nikolas Offenhauser, M.D.
  • Vincent Prinz, M.D.
  • Priv.-Doz. Johannes Woitzi, M.D.

Content

  • Basics: Models and statistics
  • Cerebrovasculature and regulation of cerebral blood flow
  • Cerebrovascular disorders (CVD) risk factors
  • Types and pathophysiology of CVD
  • Complications in stroke
  • Brain – immune interaction
  • Endogenous neuroprotection, repair and regeneration

Learning Outcome

Graduates of this module

  • know how pathophysiological processes are experimentally designed at different CVDs.
  • comprehend partial aspects of pathophysiological processes in their temporal dependence at CVDs in the acute and chronic phase
  • identify experimental approaches for a modulation of these pathophysiological processes, especially as a base for innovative therapy approaches
  • analyze advantages and interaction of in vivo and in vitro models for the pathophysiological comprehension and development of new therapy concepts
  • compare the design of experimental and clinical studies
  • compare results of animal experiments with results from clinical studies
  • assess the design of experiments
  • challenge the implication of experiments for clinical practice

Examinations

Format and weight:

  • online exam – 50 %
  • presentation – 25 %
  • take-home assignment – 25 % 

Duration (ECTS and hours)

  • 5 ECTS credits
  • 150 h, 8 weeks: 5 days or 40 h attendance phase and 110 h self-study

Module 2: Basics in Biostatistics and Clinical Trial Methodology

Karl Georg Häusler, M.D.
Karl Georg Häusler, M.D.

Scientists in Charge

  • Karl Georg Häusler, M.D.

Contributing Scientists

  • Christian von Dewitz, J.D.
  • Ulrike Grittner, Ph.D.
  • Benjamin Hotter, M.D.
  • Gerhard Jan Jungehülsing, M.D.
  • Dr. rer. medic., Dipl. Stat. Stephanie Roll
  • Prof. Philipp von Rosenstiel, M.D.
  • Carsten Schwenke, M.D.
  • Priv.-Doz. Dr. habil. Andreas Stöhr
  • Prof. Frank Wagner, M.D.
  • Alexa Ziegeler

Content

Biometry

  • Basics of medical biostatistics
  • Choosing the correct biometric methodology for respective problems
  • Interpretation of results
  • Descriptive statistics: different scale levels; table formats; graphic representations; statistic parameters
  • Confirmatory statistics: current statistical tests (chi-square and sign test; rank-sum tests; t-test; analysis of variance)
  • Linear regression and correlation analysis
  • Methods for the evaluation of diagnostic tests
  • Methods for analyzing survival data
  • Introduction into regression models (linear, logistics, Poisson, Cox)

Methods and implementation of clinical studies

  • legal and ethic principles (legal regulations, code of medical ethics, ethics commission, data privacy, patient information, among others)
  • documentation and data management in clinical studies (GCP, queries, quality management, monitoring, audits, among others)
  • Planning of studies (randomization; blinding/unblinding, selection criteria, stratification, among others)
  • pharmaceutical development and pharmaceutical security, clinical trial (definition, obligation to register, clinical trial samples, recruitment, among others)
  • Execution of clinical trials (patient education, applications for ethical review, study reports, publication of results)

Learning Outcome

Graduates of this module

  • know the basics of medical biostatistics
  • know the principles of biometric methods and statistical procedures
  • comprehend the design of clinical studies including existing legal and ethic rules
  • critically assess the benefit and significance of clinical studies for clinical practice

Examinations

Format and weight:

  • online exam – 50 %
  • presentation – 25 %
  • take-home assignment – 25 %

Duration (ECTS and hours)

  • 5 ECTS credits
  • 150 h, 8 weeks: 5 days or 40 h attendance phase and 110 h self-study

Module 3: Neuroanatomy, Cognition and Plasticity

Prof. Agnes Flöel, M.D.
Prof. Agnes Flöel, M.D.

Scientists in Charge

Prof. Agnes Flöel, M.D.

Contributing Scientists

Jens Steinbrink, Ph.D.
Heike Wersching, M.D.
Bogdan Draganski, M.D.
Prof. Hellmuth Obrig, M.D.
Prof. Christoph Ploner, M.D.
Dr. Veronica Witte
Prof. Wolfram Ziegler, Ph.D.

Content

  • Neuroanatomy and stroke syndromes
  • Neuropsychological syndromes
  • Speech disorders
  • Cognitive impairment and dementia
  • Polymorphisms in learning-relevant candidate genes
  • Environment and cognition
  • Mechanisms of learning in the healthy brain and after stroke
  • Modulation of learning

Learning Outcome

Graduates of this module

  • are familiar with the neuroanatomy of the brain, special neuropsychological syndromes after lesions, strategies for modulating the learning
  • comprehend the re-organisation of the brain through training and after specific interventions, and know which technique is best used for answering a special question regarding brain plasticity
  • identify neuropsychological deficits, dementia syndromes
  • analyze TMS data, structural and functional imaging data
  • compare different techniques for the examination of plasticity in the brain, comparison of different procedures for intervention
  • establish a connection between present knowledge regarding the plasticity in the brain and deduced intervention procedures as well as preventive approaches
  • assess the influence of life style decisions on cognitive health and the prevention of strokes
  • challenge presently postulated effects of genes to cognition; in animal experiments: postulated approaches for improving human learning

Examinations

Format and weight:

  • online exam – 50 %
  • presentation – 25 %
  • take-home assignment – 25 %

Duration (ECTS and hours)

  • 5 ECTS credits
  • 150 h, 8 weeks: 5 days or 40 h attendance phase and 110 h self-study

Module 4: Clinical Epidemiology and Health Service Research

Bob Siegerink, Ph.D.
Bob Siegerink, Ph.D.

Scientists in Charge

  • Bob Siegerink, Ph.D.

Contributing Scientists

  • Dr. oec. troph. Rebecca Muckelbauer
  • Priv.-Doz. Hannelore Neuhauser, M.D.
  • Johannes Schenkel, M.D.
  • Silke Wiedmann, Ph.D.

Content

  • Epidemiology of stroke and underlying risk factors
  • Introduction to basic principles in clinical epidemiology and health service research
  • Study desighns in epidemiology and health services research
  • Description and analysis of date in epidemiology and health serviceresearch
  • How to read and write a paper
  • Introduction in qualitative research methods

Learning Outcome

Graduates of this module

  • know the frequency of stroke as well as individual and social effects
  • comprehend the basics of clinical epidemiology and the treatment research
  • identify advantages and disadvantages of different study types in the field of epidemiology and treatment research
  • analyze epidemiological data
  • challenge the results of scientific studies

Examinations

Format and weight:

  • online exam – 50 %
  • presentation – 25 %
  • take-home assignment – 25 %

Duration (ECTS and hours)

  • 5 ECTS credits
  • 150 h, 8 weeks: 5 days or 40 h attendance phase and 110 h self-study

Module 5: Practical Training

Prof. Heinrich Audebert, M.D.
Prof. Heinrich Audebert, M.D.

Scientists in Charge

  • Prof. Heinrich Audebert, M.D.

Content

Possible practical trainings:

  • in the field of basic research
  • in the field of pharmazeutical/medical-technical research
  • in the field of patient-based clinical reasearch (med. outcome research)
  • in the field of prevention research

Practical training while clinical studies are carried out practically

  • Project management of clinical studies
  • Planning of studies including calculating the number of cases and patient recruitment (obtaining patient agreement)
  • Planning and organization of follow-up statistics

Learning Outcome

Graduates of this module

  • know the different areas of operation in the field of stroke research/stroke prevention/rehabilitation 
  • know the job situation in the different sectors of stroke care/research including clinical areas, technical facilities, science, and labs

Regarding the practical stroke treatment:

  • comprehend which pathophysiological considerations are behind the different established or treatment options under current research
  • determine for which patients the indications of different acute and rehabilitation treatments are applicable, and which criteria prevent an inclusion into therapy or study
  • analyze for how many stroke patients a treatment is relevant, and with which effects
  • compare the cost efficiency of different therapies and are able to set priorities from the patients? viewpoint as well as from a health policy viewpoint
  • establish a connection between the potentials of a stroke treatment and other links of the stroke treatment chain
  • assess the treatments? efficiency on different outcome parameters
  • call into question how well the implication of therapy measures in clinical treatment can be assessed

Examinations

Format and weight:

  • 2 written reports –  50% each

Duration (ECTS and hours)

  • 5 ECTS credits
  • 150 h, 8 weeks: two five-days practical internships and 70 h for report writing

Module 6: Imaging, Diagnostics and Rare Diseases

Prof. Jan Sobesky, M.D.
Prof. Jan Sobesky, M.D.

Scientists in Charge

  • Prof. Jan Sobesky, M.D.

Contributing Scientists

  • Georg Bohner, M.D.
  • Prof. Wolfram Döhner, M.D., Ph.D.
  • Jochen Fiebach, M.D.
  • Carsten Finke, M.D.
  • Priv.-Doz. Randolf Klingebiel, M.D.
  • Vince Madai, M.D.
  • Joan Montaner, M.D.
  • Priv.-Doz. Gabor Petzold, M.D.
  • Priv.-Doz. Stephan Schreiber, M.D.
  • Priv.-Doz. Olivier Zaro Weber, M.D.

Content

  • Acute stroke imaging
  • Functional MRImaging
  • Molecular imaging
  • Ultrasound
  • Interventional neuroradiology
  • Diagnostics in internal medicine
  • Laboratory aspects
  • Rare reasons for stroke
  • Further diagnostics
  • Differential diagnostics

Learning Outcome

Graduates of this module

  • know which imaging check-up is when indicated in the event of a stroke
  • comprehend advantages and disadvantages of the different examination methods
  • identify an ICB and an infarct as well as a vascular obliteration on MRT and CT
  • critically compare clinical studies for imaging in the event of an acute stroke
  • establish a connection between experimental approaches in MRT and the results of routine examinations

Core Competencies

Graduates of this module

  • are able to describe the optimal path for imaging during the acute and sub-acute phase of stroke
  • possess in-depth knowledge of the techniques used in stroke imaging (US, CT, MRT)
  • are able to critically judge published research findings on the topic of stroke imaging

Examinations

Format and weight:

  • online exam – 50 %
  • oral exam (OSCE) – 25 %
  • presentation – 25 %

Duration (ECTS and hours)

  • 5 ECTS credits
  • 150 h, 8 weeks: 5 days or 40 h attendance phase and 110 h self-study

Module 7: Project Management

Meike Sieveking, M.A.
Meike Sieveking, M.A.

Scientists in Charge

  • Meike Sieveking, M.A.

Contributing Scientists

  • Gerit Offenhauser
  • Jens Steinbrink, Ph.D.

Content

  • Basics
  • Phase planning
  • Time, resource and cost management
  • Documentation management
  • Project financing
  • Contract management
  • Communication
  • Quality and risk management
  • Issues of surrounding grant applications

Learning Outcome

Graduates of this module

  • know how to plan, finance, start, manage, follow-up on and finish a project
  • comprehend project management flows
  • identify problems in the project flow
  • analyze and solve difficulties in communication
  • assess the flow and the success of a project
  • challenge costs and risks

Examinations

Format and weight:

  • online exam – 50 %
  • take-home assignment – 50 %

Duration (ECTS and hours)

  • 5 ECTS credits
  • 150 h, 8 weeks: 5 days or 40 h attendance phase and 110 h self-study

Module 8: Prevention and Treatment of Stroke

Scientists in Charge

  • Daniela Bermpohl, M.D.

Contributing Scientists

  • Prof. Heinrich Audebert, M.D.
  • Prof. Jens P. Dreier, M.D.
  • Prof. Wolfram Döhner, M.D., Ph.D.
  • Prof. Stefan Hesse, M.D.
  • Gerhard Jan Jungehülsing, M.D.
  • Prof. Andreas Meisel, M.D.
  • Christian Nolte, M.D.
  • Prof. Ian Wellwood, Ph.D.

Content

  • Overview of risk factors and risk assessment
  • Primary prevention
  • Methodology
  • Acute treatment of stroke
  • Treatment of complications in stroke
  • Rehabilitation of stroke patients
  • Secondary prevention
  • Geriatric aspects in vascular medicine
  • Perspectives in stroke treatment

Learning Outcome

Graduates of this module

  • know the most important risk factors for TIA, ischemic stroke, and ICB, and can classify them according to their importance for primary prevention and secondary prevention (keywords: prevalence, risk classification, risk weighting)
  • know the international guidelines for diagnostics and therapy of an acute stroke as well as for primary and secondary prevention, and the most important studies and their results
  • identify essential problems in the assessment of vascular risk factors and their treatment as well as essential problems in the execution of clinical studies in this field
  • know the most important studies regarding acute treatment of the ischemic stroke and ICH and have learnt to challenge them
  • know the most important interfaces in the treatment of stroke patients, the different types of Stroke Units and their characteristics, as well as elemedical aspects for the treatment
  • are able to name reasons for the implication of experiments into clinical practice so far
  • are able to interpret the importance of new clinical studies for stroke treatment
  • can relate different treatment aspects with one another and combine them to an overall treatment concept
  • develop their own ideas for the evaluation of new treatment concepts

Examinations

Format and weight:

  • online exam – 50 %
  • oral exam – 25 %
  • presentation – 25 % 

Duration (ECTS and hours)

  • 5 ECTS credits
  • 150 h, 8 weeks: 5 days or 40 h attendance phase and 110 h self-study

Module 9: Master Thesis

Prof. Wolfram Döhner, M.D., Ph.D.
Prof. Wolfram Döhner, M.D., Ph.D.

Scientists in Charge

  • Prof. Wolfram Döhner, M.D., Ph.D.

Content

  • Structure of a master's thesis
  • Timing of a master's thesis
  • Literature research, database research and correct citing
  • Basic rules of scientific publications
  • Tips and pitfalls when submitting scripts
  • Correct revision of submitted scripts

Learning Outcome

Graduates of this module

  • know how to plan the master's thesis: essential contents, necessary preparation and preliminary work, and steps that have to be executed before submitting the thesis
  • understand the essential points of a thesis, understand the focus in the writing process and how it has to be executed
  • identify the steps, problems and solutions that will occur from the planning phase through to completing a thesis

Examinations

Format and weight:

  • Master thesis – 80 %
  • Defense – 20 %

Duration (ECTS and hours)

  • 20 ECTS credits
  • 600 h, 8 months
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