Professor Heinrich Audebert, M.D.

Research Group Audebert

Professor Heinrich Audebert, M.D.
Charité, Center for Stroke Research Berlin
Neurology with a focus on stroke
heinrich.audebert(at)charite.de

Profile

Heinrich Audebert is a neurologist with a focus on stroke. He is heading the Department of Neurology at the Campus Benjamin Franklin, part of the Department of Neurology at the Charité. Dr. Audebert’s major scientific interest is the implementation and evaluation of effective treatments in daily stroke care. He is therefore involved in scientific projects dealing with pre-hospital stroke care, post stroke inflammation, TeleStroke and secondary prevention.

List of Publications / Charité Research Data Base

Selected Publications

Functional outcomes of pre-hospital stroke thrombolysis in a Mobile Stroke Treatment Unit compared to conventional care: an observational registry study.
Kunz A, Ebinger M, Geisler F, Rozanski M, Waldschmidt C, Weber JE, Wendt M, Winter B, Zieschang K, Fiebach JB, Villringer K, Erdur H, Scheitz JF, Tütüncü S, Bollweg K, Grittner U, Kaczmarek S, Endres M, Nolte CH, Audebert HJ.
Lancet Neurol. 2016 Sep;15(10):1035-43. doi: 10.1016/S1474-4422(16)30129-6.
PMID:27430529

Cost-effectiveness estimate of prehospital thrombolysis: Results of the PHANTOM-S Study.
Gyrd-Hansen D, Olsen KR, Bollweg K, Kronborg C, Ebinger M, Audebert HJ. 
Neurology. 2015 Mar 17;84(11):1090-7. doi: 10.1212/WNL.0000000000001366.
PMID:25672925

Improved Prehospital Triage of Patients With Stroke in a Specialized Stroke Ambulance: Results of the Pre-Hospital Acute Neurological Therapy and Optimization of Medical Care in Stroke Study.
Wendt M, Ebinger M, Kunz A, Rozanski M, Waldschmidt C, Weber JE, Winter B, Koch PM, Freitag E, Reich J, Schremmer D, Audebert HJ; STEMO Consortium.
Stroke. 2015 Mar;46(3):740-5. doi: 10.1161/STROKEAHA.114.008159.
PMID:25634000

Effects of Golden Hour Thrombolysis A Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke (PHANTOM-S) Substudy.
Ebinger M, Kunz A, Wendt M, Rozanski M, Winter B, Waldschmidt C, Weber J, Villringer K, Fiebach JB, Audebert HJ.
JAMA Neurol. 2015 Jan;72(1):25-30. doi: 10.1001/jamaneurol.2014.3188.
PMID:25402214

Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute ischemic stroke: a randomized clinical trial.
Ebinger M, Winter B, Wendt M, Weber JE, Waldschmidt C, Rozanski M, Kunz A, Koch P, Kellner PA, Gierhake D, Villringer K, Fiebach JB, Grittner U, Hartmann A, Mackert BM, Endres M, Audebert HJ; STEMO Consortium.
JAMA. 2014 Apr 23-30;311(16):1622-31. doi: 10.1001/jama.2014.2850.
PMID:24756512

Impetus

Stroke is a medical emergency because neuronal cell death starts almost immediately after blockage of the supplying arterial vessel. Intravenous thrombolysis improves neurological outcome after ischemic stroke by increasing the rate of early recanalization of the occluded artery. However, the effectiveness of this treatment is strongly time-dependent, decreasing over time.

The potential of thrombolysis is therefore limited by pre- and intra-hospital delays in hyperacute stroke management: a delayed emergency call, time loss in ambulance management and multiple handovers at admission and during in-hospital diagnostic workup.

We have therefore started a multilevel intervention project aiming to improve all steps of hyperacute stroke management. Our stroke awareness campaign “Berlin against Stroke” took place over a six month period in 2010. Together with the Berlin Dispatch Center, we developed a stroke identification interview algorithm for emergency calls that has enabled us to recognize more than half of acute stroke patients at dispatcher level.

Most Important Projects

Protect brain

B_PROUD - Berlin Pre-hospital Or Usual Delivery of stroke care project

The objective of the B_PROUD trial B_PROUD (Berlin Pre-hospital Or Usual Delivery of stroke care project) is to show improved functional outcomes after deployment of the Stroke Emergency Mobile (STEMO) compared to regular care.
More information/project description

Protect brain

STEMO - Stroke Emergency Mobile

The STroke Emergency MObile (STEMO), a specialized ambulance vehicle, equipped with a computed tomography (CT) scanner, point of care laboratory devices and staffed with a trained team of specialists in acute stroke care (one neurologist, one paramedic and one radiology assistant) is available for prehospital thrombolysis of patients with acute ischemic stroke in Berlin, Germany.
More information/project description

Further Projects

INSPiRE (Intensified Secondary Prevention intending a Reduction of vascular re-events)
Implementation of a supported secondary prevention program in patients with minor stroke or TIA and evaluation in a randomized controlled trial.

ANNOTeM  (Acute Neurological Network in Northeast Germany with TeleMedicine support)
Implementation of a large TeleNeurology network in the states of Brandenburg and Mecklenburg-Vorpommern in order to improve acute neurological care in underserved areas.

Team

Principal Investigators

  • Prof. Dr. med. Heinrich A. Audebert, M.D. (Project Leader)
  • PD Dr. med. Martin Ebinger, M.D. Ph.D. (Vice Project Leader and Executive Emergency Physician)  

Emergency Physicians/Neurologists

  • Dr. med. Alexander Kunz, M.D.
  • Frederik Geisler, M.D.
  • Michal Rozanski, M.D.
  • Carolin Waldschmidt, M.D.
  • Dr. med. Joachim Weber, M.D.
  • Dr. med. Matthias Wendt, M.D.
  • Dr. med. Benjamin Winter, M.D.
  • Dr. med. Katja Zieschang, M.D.  

Paramedics  

  • Sandra Nagel
  • Niclas Nelke
  • Daniel Schremmer
  • Florian Stoetzer  

Computed Tomography-Technical Assistants  

  • Tadeh Akopi
  • Rouven Hopp
  • Joris Niedtfeld
  • Medschid Wesirow  

Cooperations and Research Partners

  • Berliner Feuerwehr (Berlin Fire Brigade)
  • MEYTEC GmbH Informationssysteme
  • BRAHMS GmbH (Thermo-Fisher Scientific)
  • CSB (Center for Stroke Research Berlin)
  • Deutsche Telekom (T-Systems Healthcare)
  • Roche Diagnostics

Funding

  • Technology-Foundation Berlin (TSB)
  • Investitionsbank Berlin (IBB)
  • With co-funding by the EU within the European Fonds for regional Development (EFRE)
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